聂和民

聂和民的个人简介

聂和民，男，1978年生于湖南，2009年获新加坡国立大学化学与生物分子工程博士学位，2010-2012年在纽约哥伦比亚大学医学中心从事博士后研究，2012年被聘为湖南大学教授、博士生导师。2013年起担任中国生物医学工程学会组织工程与再生医学分会理事会青年委员，2015年获“湖南省自然科学杰出青年基金”，2017年被聘为湖南大学岳麓学者，2017年起担任《Current Smart Materials》编委、湖南省生物材料学会理事、湖南省及长沙市医疗器械行业协会专家，2019年起担任中国医学装备协会转化医学分会委员。长期致力于生物材料、细胞治疗、再生医学领域的研究工作，以第一作者或通讯作者在Advanced Drug Delivery Reviews、Biomaterials、Journal of Controlled Release、ACS Applied Materials & Interfaces等杂志上发表了20余篇论文。

学术背景

湖南大学 教授

纽约市哥伦比亚大学医学中心 博士后研究科学家（Postdoctoral Research Scientist）

新加坡国立大学 研究员（Research Fellow）

新加坡国立大学 博士研究生

学术兼职

1、中国医学装备协会转化医学分会委员

2、中国生物医学工程学会组织工程与再生医学分会理事会青年委员

3、湖南省生物材料学会理事

4、《Current Smart Materials》编委

5、湖南省及长沙市医疗器械行业协会专家

研究领域

课题组的研究兴趣包括以下三方面：

1、干细胞体内迁移与细胞治疗的机制研究（Cell homing and therapy mechanisms）

2、利用生物材料构建细胞微环境（Engineering of cell niche）

3、组织（毛囊、肾脏、神经）再生（Regeneration of hair follicle,glomerularfiltrationmembrane, neuron）

科研项目

1、长沙市重点研发计划项目，kq1901024，2018/07-2021/06，主持人。

2、湖南省重点研发计划项目，2018SK2106，2018/01-2020/12，主持人。

3、国家自然科学基金面上项目，31670997，2017/01-2020/12，主持人。

4、深圳市科创委基础研究（自由探索）项目，JCYJ20160530193417959，2016/09-2018/08，主持人。

5、湖南省自然科学杰出青年基金，2015JJ1007，2015/01-2017/12，主持人。

6、湖南大学交叉学科项目，2015JCA02，2015/01-2017/12，主持人。

7、国家自然科学基金青年基金项目，31200727，2013/01-2015/12，主持人。

学术成果

1. Lin Lan, Qiuping Guo,Hemin Nie, Chang Zou, Qingyun Cai, Jin Huang, Xiangxian Meng, Linear-hairpin variable primer RT-qPCR for MicroRNA.Chemical Science, 2019, 10, 2034-2043.

2. Bei Xie, Wanzong Zhu, Pinghui Ding, Mengting Chen, Ji Li, Lei Lei, Can Zhang,Hemin Nie (*), Nanofiber scaffolds attenuate collagen synthesis of human dermal fibroblasts through TGF-β1/TSG-6 pathway,Journal of Physics: Materials, 2019, 2, 044001 (DOI: 10.1088/2515-7639/ab2563).

3. Can Zhang, Bei Xie, Yujian Zou, Dan Zhu, Lei Lei, Dapeng Zhao,Hemin Nie (*), Zero-dimensional, one-dimensional, two-dimensional and three-dimensional biomaterials for cell fate regulation,Advanced Drug Delivery Reviews, 2018, 132, 33-56.

4. Qian Li, Yun Bai, Tao jin, Shuo Wang, Wei Cui, Ilinca Stanciulescu, Rui Yang,Hemin Nie (*), Linshan Wang (*), Xing Zhang (*), Bioinspired engineering of poly(ethylene glycol) hydrogels and natural protein fibers for layered heart valve constructs,ACS Applied Materials & Interfaces, 2017, 9, 16524-16535.

5.Hemin Nie (*), Jeremy J. Mao, Micro-/nanotech-based craniofacial tissue engineering,Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine(2nd Edition), Gilson Khang, Pan Stanford Publishing, pp 660-675, United States, 2017.

6. Bei Xie, Jipeng Yi, Jian Peng, Xing Zhang, Lei Lei, Dapeng Zhao, Zhixin Lei,Hemin Nie (*), Characterization of synergistic anti-tumor effects of doxorubicin and p53 via graphene oxide-polyethyleneimine nanocarriers,Journal of Materials Science & Technology, 2017, 44, 3372-3383.

7. Cuiping Zhong, Hongwei Shen, Yu Han, Shuo Wang, Ye Wang, Xining Xu, Jianhua Qiu,Hemin Nie (*), Alginate microcapsules co-embedded with MSCs and anti-EGF mAb for the induction of hair cell-like cells in guinea pigs by taking advantage of host EGF,Journal of Materials Chemistry B, 2016, 4, 7387-7397.

8. Bei Xie, Jian Peng, Shuo Wang, Xing Zhang,Hemin Nie (*), Investigation of the sequential actions of doxorubicin and p53 on tumor cell growth via branched polyethylenimine-β-cyclodextrin conjugates,Annals of Biomedical Engineering, 2016, 4, 3372-3383.

9. Dapeng Zhao, Lei Lei, Shuo Wang,Hemin Nie (*),Understanding cell homing-based tissue engineering from the perspective of materials,Journal of Materials Chemistry B, 2015, 3, 7319-7333.

10. Shuo Wang (#), Shaoping Zhong (#), Chew Teck Lim (*),Hemin Nie (*), Effects of fiber alignment on stem cellu2013fibrous scaffold interactions,Journal of Materials Chemistry B, 2015, 3, 3358-3366.

11. Shuo Wang, Wei Ju, Peng Shang, Lei Lei,Hemin Nie (*), Coreu2013shell microspheres delivering FGF-2 and BMP-2 in different release patterns for bone regeneration,Journal of Materials Chemistry B, 2015, 3, 1907-1920.

12. Dinggeng He, Shuo Wang, Lei Lei, Zengtao Hou, Peng Shang, Xiaoxiao He,Hemin Nie (*), Coreu2013shell particles for controllable release of drug,Chemical Engineering Science, 2015, 125, 108-120.

13. Lei Lei, Shuo Wang, Honghui Wu, Wei Ju, Jian Peng, Alshurefi Anwarqahtan, Chen Chen, Yanqin Lu, Jieying Peng, Xing Zhang,Hemin Nie (*), Optimization of release pattern of FGF-2 and BMP-2 for osteogenic differentiation of low-population density hMSCs,Journal of Biomedical Materials Research Part A, 2015, 103(1), 252-261.

14.Hemin Nie, Jeremy J. Mao (*), Dental and craniofacial bioengineering,Tissue Engineering: Principles and Practices, John P Fisher, Antonios G Mikos, Joseph D Bronzino, Boca Raton : CRC Press, pp 28-1-28-17, United States, 2013.

15.Hemin Nie, Chang Hun Lee, Jiali Tan, Chuanyong Lu, Avital Mendelson, Mo Chen, Mildred C Embree, Kimi Kong, Bhranti Shah, Shuang Wang, Shoko Cho, Jeremy J Mao (*), Musculoskeletal tissue engineering by endogenous stem/progenitor cells,Cell and Tissue Research, 2012, 347(3), 665-676.

16. Zhenglin Yuan (#),Hemin Nie (#), Shuang Wang, Chang Hun Lee, Ang Li, Susan Y Fu, Hong Zhou, Lili Chen(*), Jeremy J Mao (*), Biomaterial selection for tooth regeneration,Tissue Engineering Part B Review, 2011, 17(5), 373-388.

17.Hemin Nie, Jin Kim, Susan Y. Fu, Jeremy J. Mao (*), Biomaterials Selection for Dental Pulp Regeneration,Comprehensive Biomaterials, Paul Ducheyne, Kevin Healy, Dietmar Hutmacher, Elsevier, pp 245-254, United States, 2011.

18.Hemin Nie, Yilong Fu, Chi-Hwa Wang (*), Paclitaxel and suramin-loaded core/shell microspheres in the treatment of brain tumors,Biomaterials, 2010, 31(33), 8732-8740.

19.Hemin Nie, Zhenguo Dong, Davis Yohanes Arifin, Yong Hu, Chi-Hwa Wang (*), Core/shell microspheres via coaxial electrohydrodynamic atomization for sequential and parallel release of drugs,Journal of Biomedical Materials Research Part A, 2010, 95(3), 709-716.

20.Hemin Nie, Shih Tak Khew, Lai Yeng Lee, Kai Ling Poh, Yen Wah Tong, Chi-Hwa Wang (*), Lysine-based peptide-functionalized PLGA foams for controlled DNA delivery,Journal of Controlled Release, 2009, 138(1), 64-70.

21.Hemin Nie, Mei-Ling Ho, Chih-Kuang Wang, Chi-Hwa Wang, Yin-Chih Fu (*), BMP-2 plasmid loaded PLGA/HAp composite scaffolds for treatment of bone defects in nude mice,Biomaterials, 2009, 30(5), 892-901.

22.Hemin Nie, Lai Yeng Lee, Hui Tong, Chi-Hwa Wang (*), PLGA/chitosan composites from a combination of spray drying and supercritical fluid foaming techniques: New carriers for DNA delivery,Journal of Controlled Release, 2008, 129(3), 207-214.

23.Hemin Nie, Beng Wee Soh, Yin-Chih Fu, Chi-Hwa Wang (*), Three-dimensional fibrous PLGA/HAp composite scaffold for BMP-2 delivery,Biotechnology and Bioengineering, 2008, 99(1), 223-234.

24. Yin-Chih Fu,Hemin Nie, Mei-Ling Ho, Chih-Kuang Wang, Chi-Hwa Wang (*), Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP-2,Biotechnology and Bioengineering, 2008, 99(4), 996-1006.

25.Hemin Nie, Chi-Hwa Wang (*), Fabrication and characterization of PLGA/HAp composite scaffolds for delivery of BMP-2 plasmid DNA,Journal of Controlled Release, 2007, 120(1-2), 111-121.

奖励

2019年甘肃省科技进步二等奖（排名第二）

项目名称：组织工程干细胞在感音神经性耳聋中的作用研究